The problem with studying rare genetic epilepsies is that by the time you've figured out what's going wrong, you've usually discovered seventeen other things you didn't know the brain was doing in the first place. Case in point: SLC13A5 citrate transporter disorder, a condition so rare that roughly...
Take two identical soufflés, swap one ingredient, and watch them collapse in completely different ways - that's basically what happens when two subtypes of the same prion disease attack your brain. Same devastating outcome, wildly different recipes for disaster.
Think of your brain's language system like a well-run restaurant kitchen. For decades, neuroscientists assumed all the real cooking happened upstairs in the cerebral cortex, that wrinkly outer layer hogging all the credit. The left frontal and temporal lobes were the head chefs, plating sentences...
Every decade past your twenties, your spinal cord quietly reshuffles its wiring - losing a bit of structure here, rewiring a connection there - and it does so in near-perfect lockstep with your brain, like two colleagues who never speak yet somehow always wear matching outfits.
If this were a movie, your voice would be playing a five-part role: the sound engineer mixing audio in real time, the motor director choreographing over 100 muscles, the archivist pulling files from decades of stored memories, the sensory coordinator blending vibrations from your skull with sound...
3.7 millimeters. That's the margin of error in a new tracking system that can tell exactly where a marmoset is looking in three-dimensional space while it freely wanders around, socializes, and (presumably) judges its companions. To put that in perspective, that's roughly the width of two grains of...
For years, neuroscientists operated under a tidy assumption: high-gamma activity - that buzzy, high-frequency electrical chatter (70-300 Hz) picked up by electrodes in the brain - was basically the sound of nearby neurons firing. Local neurons spike, local field potential goes up, case closed. It...
Think about the last time someone chewed with their mouth open near you. Annoying, right? Now imagine that annoyance cranked up to a full-blown fight-or-flight response - heart pounding, fists clenching, an overwhelming urge to either scream or flee the room. That's Tuesday for someone with...
Nothing happened. That's the headline. A team of researchers pointed some of the most sophisticated brain-scanning equipment on the planet at people's heads while they rested after learning, listened very carefully for signs of memory replay, and heard... absolutely nothing. Which, in science,...
The reproducibility crisis in science has been making headlines for years, but there's a quieter version of this problem hiding inside MRI machines - and a new survey paper is shining a spotlight on how researchers are fighting back.
You're using it right now - the very organ reading these words is also quietly managing your body temperature with the precision of a Swiss watchmaker. Somewhere deep in your hypothalamus, a cluster of neurons is making micro-adjustments to keep you at a comfortable 37°C, deciding when to dilate...
A 34-year-old patient sat across from me last year, three months after a stroke that damaged a sliver of her hippocampus. She could still make decisions just fine when the options were in front of her - restaurant menu, no problem. But ask her to plan a week of meals, and she'd stare at you like...
Under a microscope, a microelectrode array looks almost delicate - a tiny bed of needles, each thinner than a human hair, glinting like some miniaturized fakir's mat designed for neurons. Implanted into the motor cortex, these silicon slivers eavesdrop on the electrical chatter of brain cells that...
A protein whose entire job is to stop other proteins from being made is also one of the most important survival tools your cells have. That's the paradox at the heart of HRI, the heme-regulated inhibitor - a molecular kill switch for protein production that, counterintuitively, keeps cells alive...
When the team at TU Delft first saw the signal-to-noise ratios coming off their new graphene electrodes, they thought something was wrong with the equipment. Electrodes this small - just 10 micrometers across, roughly the width of a red blood cell - aren't supposed to pick up brain signals this...
Here's a weird one for you: the most sophisticated organ in your body - the one running 86 billion neurons, consuming 20% of your energy, and somehow keeping you from walking into traffic - can be measurably calmed by looking at some trees. Not a pill. Not a meditation app that costs $14.99 a...
The shortest version of this story: a new study suggests that what neuroscientists thought was the brain predicting upcoming words might just be a statistical quirk baked into language itself. The interesting version takes a bit longer.
The last time you stubbed your toe on the coffee table and briefly considered whether amputation was a reasonable option, your brain was secretly doing something far more interesting than just screaming. Deep inside your spinal cord, a molecular editing suite was deciding which genetic instructions...
A Netflix queue that refuses to autoplay. A vending machine that swallows your dollar and just... stares at you. Tiny brain bubbles packed with neurotransmitters that suddenly decide they're not in the mood to do their one job. Three very different things, one shared vibe: systems that have...
Most neuroscientists believe that layering brain maps on top of each other - say, comparing where genes are expressed to where brain activity lights up - reveals deep biological truth. A new review in Nature Reviews Neuroscience says: slow your roll. That map-stacking trick everyone loves? It might...